What is Southern Cheesy Chicken Spaghetti Casserole made of?

It’s made with shredded chicken, spaghetti noodles, cream of mushroom or cream of chicken soup, diced tomatoes with green chilies, and plenty of cheese. Seasonings and optional vegetables bring extra flavor, while baking ties it all together in a creamy, comforting dish.

Can you make Southern Cheesy Chicken Spaghetti Casserole ahead of time?

Yes, you can prepare the casserole up to 24 hours in advance. Cover and refrigerate until ready to bake, or freeze it unbaked for up to three months. Just add extra time when baking from frozen.

What type of chicken works best for Southern Cheesy Chicken Spaghetti Casserole?

Shredded rotisserie chicken is the most convenient option, but any cooked chicken grilled, baked, or poached works well. The key is tender, juicy meat that blends smoothly with the creamy sauce.

What side dishes go well with Southern Cheesy Chicken Spaghetti Casserole?

Pair it with fresh green beans, a simple garden salad, garlic bread, or coleslaw. These sides balance the richness of the casserole and make it a complete Southern-style meal.

Southern Cheesy Chicken Spaghetti Casserole : 7 Irresistible Tips

Name: Southern Cheesy Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 35 min
Total time: 50 min
Cuisine: Southern
Ingredients: 3 cups cooked shredded chicken (rotisserie works great); 12 oz spaghetti noodles; 1 can (10.5 oz) cream of chicken or cream of mushroom soup; 1 can (10 oz) diced tomatoes with green chilies; 1/2 cup chicken broth; 2 cups shredded cheese (cheddar, Velveeta, or blend); 1 tsp garlic powder; 1 tsp onion powder; 1/2 tsp black pepper; Optional: diced bell peppers, celery, or broccoli florets

Description

A classic Southern comfort dish made with tender chicken, creamy sauce, spaghetti, and layers of melted cheese perfect for family dinners or potlucks.

Ingredients

3 cups cooked shredded chicken (rotisserie works great)
12 oz spaghetti noodles
1 can (10.5 oz) cream of chicken or cream of mushroom soup
1 can (10 oz) diced tomatoes with green chilies
1/2 cup chicken broth
2 cups shredded cheese (cheddar, Velveeta, or blend)
1 tsp garlic powder
1 tsp onion powder
1/2 tsp black pepper
Optional: diced bell peppers, celery, or broccoli florets

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Instructions

Preheat oven to 350°F (175°C).
Cook spaghetti until al dente, then drain.
Shred chicken if not already prepared.
In a large bowl, combine soup, diced tomatoes with chilies, chicken broth, 1 cup shredded cheese, garlic powder, onion powder, and pepper.
Toss cooked spaghetti with the sauce until coated.
Grease a casserole dish and spread half the pasta mixture in it.
Sprinkle with cheese, then add the remaining pasta mixture.
Top with the rest of the cheese.
Bake 30–35 minutes until bubbly and golden.
Let rest 5–10 minutes before serving.

Notes

You can prepare ahead by refrigerating up to 24 hours before baking or freeze for up to 3 months. Try adding jalapeños or swapping cheese blends for flavor twists.

Prep Time: 15 minutes
Cook Time: 35 minutes
Category: Casserole
Method: Baked
Cuisine: Southern